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ED Treatment Plan
Updated over 3 weeks ago

Contact the provider for any problems, changes, or side effects, or if you visit a new provider for treatment. ED may indicate other health issues that should be addressed, which is why we recommend routine testing of labs and regular visits with your primary care provider.

ED may be a sign of other medical problems such as hypertension, diabetes, vascular diseases, and even neurological disorders. You must disclose your health history, medication history, and any health-related changes so the provider can address your needs to help safeguard your well-being.

Sildenafil and Tadalafil are prescription medications commonly used to help manage erectile dysfunction (ED) and should only be used after you’ve been diagnosed with ED. Take them as directed.

Below is a guide to help you understand the potential risks and benefits of Sildenafil or Tadalafil in treating ED.


These medications do not increase sexual desire. Instead, they improve the penis’s ability to fill with blood and achieve a satisfactory erection. Patients should understand that neither medication guarantees 100% success, and the success rate largely depends on the severity of the ED.

Take Note: Please review the package insert that comes with your medication and communicate honestly with your provider about any concerns.


Side Effects

Patients taking either Sildenafil or Tadalafil may experience mild to severe side effects.

Mild Side Effects:

These are relatively common and temporary, lasting a few days to weeks. However, if side effects persist longer than that, become bothersome, or worsen, contact your doctor or pharmacist.

  • Headache

  • Flushing

  • Nasal congestion / Stuffy nose

  • Muscle and joint pain

  • Dizziness

  • Stomach upset

  • Nausea

Severe Side Effects:

  • Decreased eyesight

  • Sudden decrease or loss of hearing.

  • Heart attack, stroke, or irregular heartbeats (most often in people with existing heart problems)

  • Low blood pressure

  • Anemia

  • Severe allergic reactions (e.g., difficulty breathing or wheezing, racing heart, swollen lymph nodes, swelling of the face, lips, mouth, tongue, or throat, vomiting, fever or general ill feeling, itching, skin rash, or hives, trouble swallowing or throat tightness)

  • Painful, prolonged erection (lasting more than four hours or unrelated to sexual stimulation)

Take Note: If any of these severe side effects occur, seek medical care immediately.


Warnings

  • Sildenafil and Tadalafil do not protect against sexually transmitted diseases. If you have concerns about STDs, use a condom to protect yourself and your partner.

  • These medications are phosphodiesterase type 5 (PDE5) inhibitors, which are generally safe but carry rare, serious potential side effects. They should never be taken simultaneously with nitrites or nitrates used to lower blood pressure.

  • Patients with Pulmonary Veno-Occlusive Disease (PVOD) should not use these medications.

  • Patients with a history of non-arteritic anterior ischemic optic neuropathy (NAION) should be cautious, as vision changes may be a potential side effect.

  • Dose adjustments may be necessary for patients with renal or hepatic impairment.

  • Patients must inform their provider of any cardiac history or risks, including chest pain, heart disease, high or low blood pressure, irregular heartbeats, coronary artery disease, aortic stenosis, idiopathic hypertrophic subaortic stenosis, coronary ischemia, heart attacks, strokes, heart defects, or heart failure.

  • Pilots, air traffic controllers, and drivers should not take Sildenafil (Viagra) within six hours of duty due to potential vision changes. The same applies to Tadalafil (Cialis), which can remain effective for up to 36 hours.


Medication Instructions

  • It’s generally best to take Sildenafil and Tadalafil on an empty stomach. Taking them with food, especially a fatty meal, may delay their effectiveness.

  • Avoid fatty foods at least 2 hours before taking the pill.

  • Avoid alcohol while taking these medications.

  • Do not take more than the prescribed dose within a 24-hour period.

  • It is recommended to take these medications about one hour before sexual activity.

  • Do not take Sildenafil within four (4) hours of taking an alpha-blocker to minimize the risk of hypotension. Dose adjustments may be necessary.

  • It is not recommended to take different types of ED medications simultaneously or within 48 hours of each other.

  • Do not take Sildenafil and Tadalafil together or within 48 hours of one another.


Understanding the Science behind Erections

Penile tissue releases nitric oxide (NO) when the brain processes erotic stimulation. This release of NO increases a chemical called cyclic guanosine monophosphate (cGMP), which causes the muscles in the penis to relax (tumescence), allowing blood to flow in and cause an erection. The trapped blood in the penis leads to a persistent erection.

Eventually, the penis becomes flaccid again (detumescence) when phosphodiesterases break down cGMP. Sildenafil and Tadalafil are PDE5 inhibitors, meaning they prevent the breakdown of cGMP, allowing the blood to remain in the penis longer and resulting in a more sustained erection.

Sildenafil can start working in about one hour and leaves the bloodstream within approximately eight hours. Tadalafil may take about two hours to take effect and can last up to 36 hours.


Other ways to treat ED

Other treatments for ED should be discussed with your provider:

  • Vacuum-tube device: Creates suction around the penis, drawing blood into it. A ring at the base of the penis can temporarily maintain the erection. This ring should be removed after 30 minutes to avoid tissue damage.

  • Alprostadil: Can be administered as a penile suppository or injection. It acts as a vasodilator, increasing blood flow to the penis.

  • Surgery: Options include implanting rods, inflatable implants, or semi-rigid implants.

Healthy lifestyle changes can also improve your ability to achieve and maintain an erection:

  • Healthy eating

  • Exercise

  • Adequate sleep

  • Stress management

  • Limited alcohol/nicotine intake

Alcohol acts as a depressant on the nervous system and can inhibit communication between the brain and body. Smoking can damage blood vessels and impede normal erectile function.

Contact your provider with any concerns. If you experience a medical emergency, seek treatment immediately.


Communication with your PCP

Please inform your primary care provider (PCP) that you have started taking medications for erectile dysfunction, as ED may be an early sign of conditions such as:

  • Heart disease

  • Atherosclerosis

  • High cholesterol

  • High blood pressure

  • Diabetes

  • Obesity

  • Metabolic syndrome

  • Parkinson’s disease

  • Multiple sclerosis

  • Sleep apnea

  • Prostate disease or other genitourinary diseases

  • Low testosterone

  • Psychological conditions

If you do not have a PCP, consider seeking one for comprehensive care.


Drug Interactions

While your prescribing physician has reviewed the medications you have reported, it’s important to be aware of potential drug interactions with PDE5 inhibitors.

Please review the Physician’s Desk Reference (PDR) for complete information.

Generic Name

Brand Name / other name

Treats/ Type of Medicine

Aliskiren

Tekturna

Rasilez

High Blood Pressure

Alpha-blockers

Cardura

Flomax

Hytrin

Minipress

Rapaflo

Regitine

High Blood Pressure

Enlarge Prostate

Amlodipine

Norvasc

High Blood Pressure

Amprenavir

Agenerase

HIV

Amyl Nitrite

Poppers, Rush (recreational use)

Angina/Chest pain (no longer used)

Recreational drug

Aprepitant

Emend

Nausea

Atazanavir

Reyataz

HIV

Atropine

Isopto Atropine

Eye Conditions

Boceprevir

Victrelis

Hepatitis C

Butyl Nitrate

Poppers

Rush

Liquid Gold

Recreational drug

Cariprazine

Vraylar

Psychiatric Disorders

Ceritinib

Zykadia

Cancer

Ciprofloxacin

Proquin

Cipro

Antibiotic

Clarithromycin

Biaxin

Antibiotic

Cobicistat

Tybost

HIV

Conivaptan

Vaprisol

Low Sodium in the blood

Crizotinib

Xalkori

Cancer

Darunavir

Prezista

HIV

Dasabuvir

Viekira XR

Viekira Pak–contains Ritonavir*

Hepatitis C

Delavirdine

Rescriptor

HIV

Dihydroergotamine

Migranal

Migraines

Diltiazem

Cartia

Cardizem

Dilacor XR

Tiazac

High Blood Pressure

Angina

Dronedarone

Multaq

Irregular Heartbeats

Erythromycin

Erythrocin

Ery-Tab

E-Mycin

Eryc

Antibiotic

Fluconazole

Diflucan

Fungal

Yeast Infections

Fluvoxamine

Faverin

Fevarin

Floxyfral

Dumyrox

Luvox

Obsessive Compulsive Disorder (OCD)

Fosamprenavir

Lexiva

HIV

Idelalisib

Zydelig

Cancer–Leukemia

Imatinib

Gleevec

Cancer

Indinavir

Crixivan

HIV

Isavuconazonium

Cresemba

Fungal Infections

Isosorbide Dinitrate/ Monohydrate

Isordil Titradose

Dilatrate-SR

Imdur

Ismo

Monoket

IsoDitrate

Heart Disease

Chest Pain

Itraconazole

Sporanox

Onmel

Fungal and Yeast

Ivacaftor

Kalydeco

Cystic Fibrosis

Lopinavir; Ritonavir

Kaletra

Contains Ritonavir and Treats HIV

Lorcaserin

Belviq

Weight Control

Lurasidone

Latuda

Schizophrenia and Bipolar depression

Mifepristone, RU-486

Korlym

Mifeprex

Ends Pregnancy

Mitotane

Lysodren

Cancer

Cushing‘s Syndrome

Monoamine oxidase inhibitors

Azilect

Marplan

Nardil

Parnate

Depression

Nebivolol

Bystolic

High Blood Pressure

Nelfinavir

Viracept

HIV

Nesiritide

Natrecor

Heart Failure but is an IV drug

Netupitant

Akynzeo

Nausea

Vomiting

Nifedipine

Procardia

Nifedical XL

Adalat

Hypertension and Angina

Nilotinib

Tasigna

Cancer–Leukemia

Nitrates

Isordil Titradose

Dilatrate-SR

Imdur

Imdur ER

Ismo

Monoket

IsoDitrate

Heart Disease

Chest Pain

Nitroglycerin

Nitro-bid

Nitrocot SA Capsule

Nitro-dur

Nitrostat

Nitrodisc

Nitrek transdermal

Minitran

Nitrol ointment

Transderm-Nitro

Nitro-Time

Nitrotab

NitroMist

Nitro-Par

Nitrolingual

Nitroquick

Nitrogard

Nitroglyn

Nitrong

Chest Pain

Heart Conditions

Nitroprusside

Nipride RTU

Nitropress

Heart Failure

Hypertensive crisis

Ombitasvir; Paritaprevir; Ritonavir

Technivie

Viekira Pak

Hepatitis C

Phenoxybenzamine

Dibenzyline

High Blood Pressure

Pheochromocytoma

Phentolamine

Regitine

Oraverse

Erectile Dysfunction

High Blood Pressure

Posaconazole

Noxafil

Fungal Infections

Prazosin

Minipress

Vasoflex

Lentopres

Hypovase

High Blood Pressure

PTSD

Anxiety

Ribociclib

Kisqali

Cancer

Riociguat

Adempas

High Blood Pressure in the Arteries of the Lung

Ritonavir

Norvir

Also found in

Technivie

Viekira Pak

HIV

Hepatitis C

Sapropterin

Kuvan

Treats a disorder that causes amino acid buildup

Saquinavir

Invirase

Fortovase

HIV

Silodosin

Rapaflo

Enlarged Prostate

Tacrolimus

Prograft

Advagraf XL

Protopic

Hecoria

Organ Transplants

Tamsulosin

Flomax

Enlarged Prostate

Telaprevir

Incivek

Incivo

Hepatitis C

Telithromycin

Ketek

Antibiotic

Telotristat Ethyl

Xermelo

Diarrhea in cancer patients

Terazosin

Hytrin

High Blood Pressure

Enlarged prostate

Tipranavir

Aptivus

HIV

Verapamil

Calan

Isoptin

High Blood Pressure

Angina

Irregular Heart Beats

Voriconazole

Vfend

Fungal Infection



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