Contact the provider for any problems, changes, or side effects, or if you visit a new provider for treatment. ED may indicate other health issues that should be addressed, which is why we recommend routine testing of labs and regular visits with your primary care provider.
ED may be a sign of other medical problems such as hypertension, diabetes, vascular diseases, and even neurological disorders. You must disclose your health history, medication history, and any health-related changes so the provider can address your needs to help safeguard your well-being.
Sildenafil and Tadalafil are prescription medications commonly used to help manage erectile dysfunction (ED) and should only be used after you’ve been diagnosed with ED. Take them as directed.
Below is a guide to help you understand the potential risks and benefits of Sildenafil or Tadalafil in treating ED.
These medications do not increase sexual desire. Instead, they improve the penis’s ability to fill with blood and achieve a satisfactory erection. Patients should understand that neither medication guarantees 100% success, and the success rate largely depends on the severity of the ED.
Take Note: Please review the package insert that comes with your medication and communicate honestly with your provider about any concerns.
Side Effects
Patients taking either Sildenafil or Tadalafil may experience mild to severe side effects.
Mild Side Effects:
These are relatively common and temporary, lasting a few days to weeks. However, if side effects persist longer than that, become bothersome, or worsen, contact your doctor or pharmacist.
Headache
Flushing
Nasal congestion / Stuffy nose
Muscle and joint pain
Dizziness
Stomach upset
Nausea
Severe Side Effects:
Decreased eyesight
Sudden decrease or loss of hearing.
Heart attack, stroke, or irregular heartbeats (most often in people with existing heart problems)
Low blood pressure
Anemia
Severe allergic reactions (e.g., difficulty breathing or wheezing, racing heart, swollen lymph nodes, swelling of the face, lips, mouth, tongue, or throat, vomiting, fever or general ill feeling, itching, skin rash, or hives, trouble swallowing or throat tightness)
Painful, prolonged erection (lasting more than four hours or unrelated to sexual stimulation)
Take Note: If any of these severe side effects occur, seek medical care immediately.
Warnings
Sildenafil and Tadalafil do not protect against sexually transmitted diseases. If you have concerns about STDs, use a condom to protect yourself and your partner.
These medications are phosphodiesterase type 5 (PDE5) inhibitors, which are generally safe but carry rare, serious potential side effects. They should never be taken simultaneously with nitrites or nitrates used to lower blood pressure.
Patients with Pulmonary Veno-Occlusive Disease (PVOD) should not use these medications.
Patients with a history of non-arteritic anterior ischemic optic neuropathy (NAION) should be cautious, as vision changes may be a potential side effect.
Dose adjustments may be necessary for patients with renal or hepatic impairment.
Patients must inform their provider of any cardiac history or risks, including chest pain, heart disease, high or low blood pressure, irregular heartbeats, coronary artery disease, aortic stenosis, idiopathic hypertrophic subaortic stenosis, coronary ischemia, heart attacks, strokes, heart defects, or heart failure.
Pilots, air traffic controllers, and drivers should not take Sildenafil (Viagra) within six hours of duty due to potential vision changes. The same applies to Tadalafil (Cialis), which can remain effective for up to 36 hours.
Medication Instructions
It’s generally best to take Sildenafil and Tadalafil on an empty stomach. Taking them with food, especially a fatty meal, may delay their effectiveness.
Avoid fatty foods at least 2 hours before taking the pill.
Avoid alcohol while taking these medications.
Do not take more than the prescribed dose within a 24-hour period.
It is recommended to take these medications about one hour before sexual activity.
Do not take Sildenafil within four (4) hours of taking an alpha-blocker to minimize the risk of hypotension. Dose adjustments may be necessary.
It is not recommended to take different types of ED medications simultaneously or within 48 hours of each other.
Do not take Sildenafil and Tadalafil together or within 48 hours of one another.
Understanding the Science behind Erections
Penile tissue releases nitric oxide (NO) when the brain processes erotic stimulation. This release of NO increases a chemical called cyclic guanosine monophosphate (cGMP), which causes the muscles in the penis to relax (tumescence), allowing blood to flow in and cause an erection. The trapped blood in the penis leads to a persistent erection.
Eventually, the penis becomes flaccid again (detumescence) when phosphodiesterases break down cGMP. Sildenafil and Tadalafil are PDE5 inhibitors, meaning they prevent the breakdown of cGMP, allowing the blood to remain in the penis longer and resulting in a more sustained erection.
Sildenafil can start working in about one hour and leaves the bloodstream within approximately eight hours. Tadalafil may take about two hours to take effect and can last up to 36 hours.
Other ways to treat ED
Other treatments for ED should be discussed with your provider:
Vacuum-tube device: Creates suction around the penis, drawing blood into it. A ring at the base of the penis can temporarily maintain the erection. This ring should be removed after 30 minutes to avoid tissue damage.
Alprostadil: Can be administered as a penile suppository or injection. It acts as a vasodilator, increasing blood flow to the penis.
Surgery: Options include implanting rods, inflatable implants, or semi-rigid implants.
Healthy lifestyle changes can also improve your ability to achieve and maintain an erection:
Healthy eating
Exercise
Adequate sleep
Stress management
Limited alcohol/nicotine intake
Alcohol acts as a depressant on the nervous system and can inhibit communication between the brain and body. Smoking can damage blood vessels and impede normal erectile function.
Contact your provider with any concerns. If you experience a medical emergency, seek treatment immediately.
Communication with your PCP
Please inform your primary care provider (PCP) that you have started taking medications for erectile dysfunction, as ED may be an early sign of conditions such as:
Heart disease
Atherosclerosis
High cholesterol
High blood pressure
Diabetes
Obesity
Metabolic syndrome
Parkinson’s disease
Multiple sclerosis
Sleep apnea
Prostate disease or other genitourinary diseases
Low testosterone
Psychological conditions
If you do not have a PCP, consider seeking one for comprehensive care.
Drug Interactions
While your prescribing physician has reviewed the medications you have reported, it’s important to be aware of potential drug interactions with PDE5 inhibitors.
Please review the Physician’s Desk Reference (PDR) for complete information.
Generic Name | Brand Name / other name | Treats/ Type of Medicine |
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Aliskiren | Tekturna Rasilez | High Blood Pressure |
Alpha-blockers | Cardura Flomax Hytrin Minipress Rapaflo Regitine | High Blood Pressure
Enlarge Prostate |
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Amlodipine | Norvasc | High Blood Pressure |
Amprenavir | Agenerase | HIV |
Amyl Nitrite | Poppers, Rush (recreational use) | Angina/Chest pain (no longer used)
Recreational drug |
Aprepitant | Emend | Nausea |
Atazanavir | Reyataz | HIV |
Atropine | Isopto Atropine | Eye Conditions |
Boceprevir | Victrelis | Hepatitis C |
Butyl Nitrate | Poppers Rush Liquid Gold | Recreational drug |
|
|
|
|
|
|
Cariprazine | Vraylar | Psychiatric Disorders |
Ceritinib | Zykadia | Cancer |
|
|
|
Ciprofloxacin | Proquin Cipro | Antibiotic |
Clarithromycin | Biaxin | Antibiotic |
|
|
|
Cobicistat | Tybost | HIV |
Conivaptan | Vaprisol | Low Sodium in the blood |
Crizotinib | Xalkori | Cancer |
Darunavir | Prezista | HIV |
Dasabuvir | Viekira XR Viekira Pak–contains Ritonavir* | Hepatitis C |
Delavirdine | Rescriptor | HIV |
Dihydroergotamine | Migranal | Migraines |
Diltiazem | Cartia Cardizem Dilacor XR Tiazac | High Blood Pressure Angina |
|
|
|
Dronedarone | Multaq | Irregular Heartbeats |
|
|
|
Erythromycin | Erythrocin Ery-Tab E-Mycin Eryc | Antibiotic |
Fluconazole | Diflucan | Fungal Yeast Infections |
|
|
|
Fluvoxamine | Faverin Fevarin Floxyfral Dumyrox Luvox | Obsessive Compulsive Disorder (OCD) |
Fosamprenavir | Lexiva | HIV |
Idelalisib | Zydelig | Cancer–Leukemia |
Imatinib | Gleevec | Cancer |
Indinavir | Crixivan | HIV |
Isavuconazonium | Cresemba | Fungal Infections |
|
|
|
Isosorbide Dinitrate/ Monohydrate | Isordil Titradose Dilatrate-SR Imdur Ismo Monoket IsoDitrate | Heart Disease Chest Pain |
Itraconazole | Sporanox Onmel | Fungal and Yeast |
Ivacaftor | Kalydeco | Cystic Fibrosis |
|
|
|
Lopinavir; Ritonavir | Kaletra | Contains Ritonavir and Treats HIV |
Lorcaserin | Belviq | Weight Control |
Lurasidone | Latuda | Schizophrenia and Bipolar depression |
Mifepristone, RU-486 | Korlym Mifeprex | Ends Pregnancy |
Mitotane | Lysodren | Cancer Cushing‘s Syndrome |
Monoamine oxidase inhibitors | Azilect Marplan Nardil Parnate | Depression |
Nebivolol | Bystolic | High Blood Pressure |
Nelfinavir | Viracept | HIV |
Nesiritide | Natrecor | Heart Failure but is an IV drug |
Netupitant | Akynzeo | Nausea Vomiting |
Nifedipine | Procardia Nifedical XL Adalat | Hypertension and Angina |
Nilotinib | Tasigna | Cancer–Leukemia |
Nitrates | Isordil Titradose Dilatrate-SR Imdur Imdur ER Ismo Monoket IsoDitrate | Heart Disease Chest Pain |
Nitroglycerin | Nitro-bid Nitrocot SA Capsule Nitro-dur Nitrostat Nitrodisc Nitrek transdermal Minitran Nitrol ointment Transderm-Nitro Nitro-Time Nitrotab NitroMist Nitro-Par Nitrolingual Nitroquick Nitrogard Nitroglyn Nitrong | Chest Pain Heart Conditions |
Nitroprusside | Nipride RTU Nitropress | Heart Failure Hypertensive crisis |
Ombitasvir; Paritaprevir; Ritonavir | Technivie Viekira Pak | Hepatitis C |
Phenoxybenzamine | Dibenzyline | High Blood Pressure Pheochromocytoma |
Phentolamine | Regitine Oraverse | Erectile Dysfunction High Blood Pressure |
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|
|
Posaconazole | Noxafil | Fungal Infections |
Prazosin | Minipress Vasoflex Lentopres Hypovase | High Blood Pressure PTSD Anxiety |
Ribociclib | Kisqali | Cancer |
Riociguat | Adempas | High Blood Pressure in the Arteries of the Lung |
Ritonavir | Norvir Also found in Technivie Viekira Pak | HIV Hepatitis C |
Sapropterin | Kuvan | Treats a disorder that causes amino acid buildup |
Saquinavir | Invirase Fortovase | HIV |
Silodosin | Rapaflo | Enlarged Prostate |
Tacrolimus | Prograft Advagraf XL Protopic Hecoria | Organ Transplants |
Tamsulosin | Flomax | Enlarged Prostate |
Telaprevir | Incivek Incivo | Hepatitis C |
Telithromycin | Ketek | Antibiotic |
Telotristat Ethyl | Xermelo | Diarrhea in cancer patients |
Terazosin | Hytrin | High Blood Pressure Enlarged prostate |
Tipranavir | Aptivus | HIV |
Verapamil | Calan Isoptin | High Blood Pressure Angina Irregular Heart Beats |
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Voriconazole | Vfend | Fungal Infection |